Immune modulation by parenteral lipid emulsions
نویسندگان
چکیده
منابع مشابه
Immune modulation by parenteral lipid emulsions.
Total parenteral nutrition is the final option for nutritional support of patients with severe intestinal failure. Lipid emulsions constitute the main source of fuel calories and fatty acids (FAs) in parenteral nutrition formulations. However, adverse effects on patient outcomes have been attributed to the use of lipids, mostly in relation to impaired immune defenses and altered inflammatory re...
متن کاملNew parenteral lipid emulsions for clinical use.
Routine use of parenteral lipid emulsions (LE) in clinical practice began in 1961, with the development of soybean oil (SO) - based LE. Although clinically safe, experimental reports indicated that SO-based LE could exert a negative influence on immunological functions. Those findings were related to its absolute and relative excess of omega-6 polyunsaturated fatty acids (PUFA) and the low amou...
متن کاملSteroidal Compounds in Commercial Parenteral Lipid Emulsions
Parenteral nutrition lipid emulsions made from various plant oils contain steroidal compounds, called phytosterols. During parenteral administration of lipid emulsions, phytosterols can reach levels in the blood that are many fold higher than during enteral administration. The elevated phytosterol levels have been associated with the development of liver dysfunction and the rare development of ...
متن کاملPlasma lipid levels in preterm neonates receiving parenteral fat emulsions.
Concentrations of various plasma lipid fractions were determined during 96 hours of continuous parenteral infusions of lipid emulsions in 10 normally-grown neonates whose birth-weights ranged from 960 to 1760 g and whose gestational ages ranged from 26 to 32 weeks. Total lipid, triglyceride, free glycerol, and free fatty acid concentrations were measured. During lipid infusions, mean plasma con...
متن کاملBenefits of Parenteral Lipid Emulsions in Acute Respiratory Failure
Lipid emulsions in parenteral nutrition can interfere with pulmonary functions in patients displaying anomalies of the ventilation-perfusion ratio. The underlying mechanisms are unknown, but involve modifications of the production of vasoconstrictor and vasodilator eicosanoids as an effect of lipid infusion. Preferential synthesis of one or other of the eicosanoid types depends on the rate of a...
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ژورنال
عنوان ژورنال: The American Journal of Clinical Nutrition
سال: 2007
ISSN: 0002-9165,1938-3207
DOI: 10.1093/ajcn/85.5.1171